Uncovering low-dimensional, miR-based signatures of acute myeloid and lymphoblastic leukemias with a machine-learning-driven network approach

por Candia, Julián, Cherukuri, Srujana, Guo, Yin, Doshi, Kshama A., Banavar, Jayanth R., Civin, Curt I., Losert, Wolfgang
Publicado en Converg Sci Phys Oncol (2015)

The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentration...

por Mathias, Trevor J., Natarajan, Karthika, Shukla, Suneet, Doshi, Kshama A., Singh, Zeba N., Ambudkar, Suresh V., Baer, Maria R.
Publicado en Invest New Drugs (2015)

Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress

por Doshi, Kshama A., Trotta, Rossana, Natarajan, Karthika, Rassool, Feyruz V., Tron, Adriana E., Huszar, Dennis, Perrotti, Danilo, Baer, Maria R.
Publicado en Oncotarget (2016)

Concurrent inhibition of Pim and FLT3 kinases enhances apoptosis of FLT3-ITD acute myeloid leukemia cells through increased Mcl-1 proteasomal degradation

por Kapoor, Shivani, Natarajan, Karthika, Baldwin, Patrick R., Doshi, Kshama A., Lapidus, Rena G., Mathias, Trevor J., Scarpa, Mario, Trotta, Rossana, Davila, Eduardo, Kraus, Manfred, Huszar, Dennis, Tron, Adriana E., Perrotti, Danilo, Baer, Maria R.
Publicado en Clin Cancer Res (2017)