High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature

Human induced pluripotent stem cells (hiPSCs) are reprogrammed from adult or progenitor somatic cells and must make substantial adaptations to ensure genomic stability in order to become “embryonic stem cell- (ESC-) like.” The DNA damage response (DDR) is critical for maintenance of such genomic int...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Stem Cells Int
Prif Awduron: Nagaria, Pratik K., Robert, Carine, Park, Tea Soon, Huo, Jeffrey S., Zambidis, Elias T., Rassool, Feyruz V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Hindawi Publishing Corporation 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023833/
https://ncbi.nlm.nih.gov/pubmed/27688775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/3826249
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