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Human iPSCs harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining hESC-like metabolic reprogramming

Human induced pluripotent stem cells (iPSCs) have been recently found to harbor genomic alterations. However, the integrity of mitochondrial DNA (mtDNA) within reprogrammed cells has yet to be investigated. mtDNA mutations occur at a high rate and are believed to contribute to the pathology of a num...

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Detaylı Bibliyografya
Yayımlandı:Stem Cells
Asıl Yazarlar: Prigione, Alessandro, Lichtner, Björn, Kuhl, Heiner, Struys, Eduard A., Wamelink, Mirjam, Lehrach, Hans, Ralser, Markus, Timmermann, Bernd, Adjaye, James
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730046/
https://ncbi.nlm.nih.gov/pubmed/24123565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1552
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