High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature

Human induced pluripotent stem cells (hiPSCs) are reprogrammed from adult or progenitor somatic cells and must make substantial adaptations to ensure genomic stability in order to become “embryonic stem cell- (ESC-) like.” The DNA damage response (DDR) is critical for maintenance of such genomic int...

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Udgivet i:Stem Cells Int
Main Authors: Nagaria, Pratik K., Robert, Carine, Park, Tea Soon, Huo, Jeffrey S., Zambidis, Elias T., Rassool, Feyruz V.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023833/
https://ncbi.nlm.nih.gov/pubmed/27688775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/3826249
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