Depletion of Cytotoxic T-Cells Does Not Protect NUP98-HOXD13 Mice from Myelodysplastic Syndrome but Reveals a Modest Tumor Immunosurveillance Effect

door Gough, Sheryl M., Chung, Yang Jo, Aplan, Peter D.
Gepubliceerd in 2012

Myeloablative hematopoietic stem cell transplantation improves survival but is not curative in a pre-clinical model of myelodysplastic syndrome

door Chung, Yang Jo, Fry, Terry J., Aplan, Peter D.
Gepubliceerd in PLoS One (2017)

Expression of a CALM‐AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice

door Caudell, David, Zhang, Zhenhua, Chung, Yang Jo, Aplan, Peter D.
Gepubliceerd in 2007

Impaired differentiation and apoptosis of hematopoietic precursors in a mouse model of myelodysplastic syndrome

door Choi, Chul Won, Chung, Yang Jo, Slape, Christopher, Aplan, Peter D.
Gepubliceerd in 2008

A NUP98-HOXD13 fusion gene impairs differentiation of B and T lymphocytes and leads to expansion of thymocytes with partial TCRB gene rearrangement

door Choi, Chul Won, Chung, Yang Jo, Slape, Christopher, Aplan, Peter D.
Gepubliceerd in 2009

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

door Chung, Yang Jo, Khawaja, Ghanwa, Wolcott, Karen M., Aplan, Peter D.
Gepubliceerd in J Vis Exp (2018)

Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.

door Slape, Christopher, Chung, Yang Jo, Soloway, Paul D., Tessarollo, Lino, Aplan, Peter D
Gepubliceerd in 2007

Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell

door Chung, Yang Jo, Choi, Chul Won, Slape, Christopher, Fry, Terry, Aplan, Peter D.
Gepubliceerd in 2008

Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome

door Chung, Yang Jo, Robert, Carine, Gough, Sheryl M., Rassool, Feyruz V., Aplan, Peter D.
Gepubliceerd in 2013

Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia

door Beachy, Sarah H., Onozawa, Masahiro, Silverman, Deborah, Chung, Yang Jo, Rivera, Mariela Martinez, Aplan, Peter D.
Gepubliceerd in 2013

Thymic precursor cells generate acute myeloid leukemia in NUP98-PHF23/NUP98-HOXD13 double transgenic mice

door Kundu, Subhadip, Park, Eun Sil, Chung, Yang Jo, Walker, Robert L., Zhu, Yuelin J., Negi, Vijay, Meltzer, Paul S., Aplan, Peter D.
Gepubliceerd in Sci Rep (2019)

Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background

door Yin, Mianmian, Chung, Yang Jo, Lindsley, R. Coleman, Walker, Robert L., Zhu, Yuelin J., Ebert, Benjamin L., Meltzer, Paul S., Aplan, Peter D.
Gepubliceerd in Blood (2019)

Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma

door Beachy, Sarah H., Onozawa, Masahiro, Chung, Yang Jo, Slape, Chris, Bilke, Sven, Francis, Princy, Pineda, Marbin, Walker, Robert L., Meltzer, Paul, Aplan, Peter D.
Gepubliceerd in 2012

Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels

door Zhou, Weixin, Chung, Yang Jo, Parrilla Castellar, Edgardo R., Zheng, Ying, Chung, Hye-Jung, Bandle, Russell, Liu, Juhong, Tessarollo, Lino, Batchelor, Eric, Aplan, Peter D., Levens, David
Gepubliceerd in Am J Pathol (2016)

Somatic mutations in murine models of leukemia and lymphoma: disease specificity and clinical relevance

door Goldberg, Liat, Gough, Sheryl M, Lee, Fan, Dang, Christine, Walker, Robert L., Zhu, Yeulin J., Bilke, Sven, Pineda, Marbin, Onozawa, Masahiro, Chung, Yang Jo, Meltzer, Paul S., Aplan, Peter D.
Gepubliceerd in Genes Chromosomes Cancer (2017)

Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis

door Stumpo, Deborah J., Broxmeyer, Hal E., Ward, Toni, Cooper, Scott, Hangoc, Giao, Chung, Yang Jo, Shelley, William C., Richfield, Eric K., Ray, Manas K., Yoder, Mervin C., Aplan, Peter D., Blackshear, Perry J.
Gepubliceerd in 2009

Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways

door Gough, Sheryl M., Goldberg, Liat, Pineda, Marbin, Walker, Robert L., Zhu, Yuelin J., Bilke, Sven, Chung, Yang Jo, Dufraine, Joseph, Kundu, Subhadip, Jacoby, Elad, Fry, Terry J., Fischer, Susanna, Panzer-Grümayer, Renate, Meltzer, Paul S., Aplan, Peter D.
Gepubliceerd in Blood Adv (2017)

CENP-A overexpression promotes aneuploidy with karyotypic heterogeneity

door Shrestha, Roshan L., Rossi, Austin, Wangsa, Darawalee, Hogan, Ann K., Zaldana, Kimberly S., Suva, Evelyn, Chung, Yang Jo, Sanders, Chelsea L., Difilippantonio, Simone, Karpova, Tatiana S., Karim, Baktiar, Foltz, Daniel R., Fachinetti, Daniele, Aplan, Peter D., Ried, Thomas, Basrai, Munira A.
Gepubliceerd in J Cell Biol (2021)

NUP98-PHF23 is a chromatin modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD domain histone reader function

door Gough, Sheryl M, Lee, Fan, Yang, Fan, Walker, Robert L, Zhu, Yeulin J, Pineda, Marbin, Onozawa, Masahiro, Chung, Yang Jo, Bilke, Sven, Wagner, Elise K, Denu, John M, Ning, Yi, Xu, Bowen, Wang, Gang Greg, Meltzer, Paul S, Aplan, Peter D
Gepubliceerd in 2014

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

door Sun, Jie, He, Xin, Zhu, Yinghui, Ding, Zonghui, Dong, Haojie, Feng, Yimei, Du, Juan, Wang, Hanying, Wu, Xiwei, Zhang, Lei, Yu, Xiaochun, Lin, Allen, McDonald, Tinisha, Zhao, Dandan, Wu, Herman, Hua, Wei-Kai, Zhang, Bin, Feng, Lifeng, Tohyama, Kaoru, Bhatia, Ravi, Oberdoerffer, Philipp, Chung, Yang Jo, Apian, Peter D., Boultwood, Jacqueline, Pellagatti, Andrea, Khaled, Samer, Kortylewski, Marcin, Pichiorri, Flavia, Kuo, Ya-Huei, Carlesso, Nadia, Marcucci, Guido, Jin, Hongchuan, Li, Ling
Gepubliceerd in Cell Stem Cell (2018)