The role of haploinsufficiency of RPS14 and p53 activation in the molecular pathogenesis of the 5q- syndrome

Por Boultwood, Jacqueline
Publicado em 2011

Recent Advances in the 5q- Syndrome

Por Pellagatti, Andrea, Boultwood, Jacqueline
Publicado no Mediterr J Hematol Infect Dis (2015)

Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression

Por Jädersten, Martin, Saft, Leonie, Pellagatti, Andrea, Göhring, Gudrun, Wainscoat, James S., Boultwood, Jacqueline, Porwit, Anna, Schlegelberger, Brigitte, Hellström-Lindberg, Eva
Publicado em 2009

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome

Por Pandolfi, Ashley, Stanley, Robert F., Yu, Yiting, Bartholdy, Boris, Pendurti, Gopichand, Gritsman, Kira, Boultwood, Jacqueline, Chernoff, Jonathan, Verma, Amit, Steidl, Ulrich
Publicado no Blood (2015)

CSNK1A1 mutations and gene expression analysis in myelodysplastic syndromes with del(5q)

Por Bello, Erica, Pellagatti, Andrea, Shaw, Jacqueline, Mecucci, Cristina, Kušec, Rajko, Killick, Sally, Giagounidis, Aristoteles, Raynaud, Sophie, Calasanz, María J., Fenaux, Pierre, Boultwood, Jacqueline
Publicado no Br J Haematol (2015)

Targeted re-sequencing analysis of 25 genes commonly mutated in myeloid disorders in del(5q) myelodysplastic syndromes

Por Fernandez-Mercado, Marta, Burns, Adam, Pellagatti, Andrea, Giagounidis, Aristoteles, Germing, Ulrich, Agirre, Xabier, Prosper, Felipe, Aul, Carlo, Killick, Sally, Wainscoat, James S., Schuh, Anna, Boultwood, Jacqueline
Publicado em 2013

Expression of microRNAs in diffuse large B cell lymphoma is associated with immunophenotype, survival and transformation from follicular lymphoma

Por Lawrie, Charles H, Chi, Jianxiang, Taylor, Stephen, Tramonti, Daniela, Ballabio, Erica, Palazzo, Stefano, Saunders, Nigel J, Pezzella, Francesco, Boultwood, Jacqueline, Wainscoat, James S, Hatton, Christian S R
Publicado no J Cell Mol Med (2009)

Meta-Analysis of Microarray Studies Reveals a Novel Hematopoietic Progenitor Cell Signature and Demonstrates Feasibility of Inter-Platform Data Integration

Por Sohal, Davendra, Yeatts, Andrew, Ye, Kenny, Pellagatti, Andrea, Zhou, Li, Pahanish, Perry, Mo, Yongkai, Bhagat, Tushar, Mariadason, John, Boultwood, Jacqueline, Melnick, Ari, Greally, John, Verma, Amit
Publicado em 2008

Haploinsufficiency of RPS14 in 5q− syndrome is associated with deregulation of ribosomal- and translation-related genes

Por Pellagatti, Andrea, Hellström-Lindberg, Eva, Giagounidis, Aristoteles, Perry, Janet, Malcovati, Luca, Della Porta, Matteo G, Jädersten, Martin, Killick, Sally, Fidler, Carrie, Cazzola, Mario, Wainscoat, James S, Boultwood, Jacqueline
Publicado em 2008

Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q− syndrome patients

Por Pellagatti, Andrea, Jädersten, Martin, Forsblom, Ann-Mari, Cattan, Helen, Christensson, Birger, Emanuelsson, Emma K., Merup, Mats, Nilsson, Lars, Samuelsson, Jan, Sander, Birgitta, Wainscoat, James S., Boultwood, Jacqueline, Hellström-Lindberg, Eva
Publicado em 2007

MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival

Por Chi, Jianxiang, Ballabio, Erica, Chen, Xiao-He, Kušec, Rajko, Taylor, Steve, Hay, Deborah, Tramonti, Daniela, Saunders, Nigel J, Littlewood, Timothy, Pezzella, Francesco, Boultwood, Jacqueline, Wainscoat, James S, Hatton, Christian SR, Lawrie, Charles H
Publicado em 2011

Genomic Imbalances Are Confined to Non-Proliferating Cells in Paediatric Patients with Acute Myeloid Leukaemia and a Normal or Incomplete Karyotype

Por Ballabio, Erica, Regan, Regina, Garimberti, Elisa, Harbott, Jochen, Bradtke, Jutta, Teigler-Schlegel, Andrea, Biondi, Andrea, Cazzaniga, Giovanni, Giudici, Giovanni, Wainscoat, James S., Boultwood, Jacqueline, Bridger, Joanna M., Knight, Samantha J. L., Tosi, Sabrina
Publicado em 2011

ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts

Por Valletta, Simona, Dolatshad, Hamid, Bartenstein, Matthias, Yip, Bon Ham, Bello, Erica, Gordon, Shanisha, Yu, Yiting, Shaw, Jacqueline, Roy, Swagata, Scifo, Laura, Schuh, Anna, Pellagatti, Andrea, Fulga, Tudor A., Verma, Amit, Boultwood, Jacqueline
Publicado no Oncotarget (2015)

PRPF8 Defects Cause Missplicing in Myeloid Malignancies

Por Kurtovic-Kozaric, Amina, Przychodzen, Bartlomiej, Singh, Jarnail, Konarska, Maria M., Clemente, Michael J., Otrock, Zaher K., Nakashima, Meghan, Hsi, Eric D., Yoshida, Kenichi, Ogawa, Seishi, Boultwood, Jacqueline, Maciejewski, Jaroslaw P., Padgett, Richard A., Makishima, Hideki
Publicado em 2014

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells

Por Schinke, Carolina, Giricz, Orsolya, Li, Weijuan, Shastri, Aditi, Gordon, Shanisha, Barreyro, Laura, Bhagat, Tushar, Bhattacharyya, Sanchari, Ramachandra, Nandini, Bartenstein, Matthias, Pellagatti, Andrea, Boultwood, Jacqueline, Wickrema, Amittha, Yu, Yiting, Will, Britta, Wei, Sheng, Steidl, Ulrich, Verma, Amit
Publicado no Blood (2015)

The Role of the Iron Transporter ABCB7 in Refractory Anemia with Ring Sideroblasts

Por Boultwood, Jacqueline, Pellagatti, Andrea, Nikpour, Maryam, Pushkaran, Beena, Fidler, Carrie, Cattan, Helen, Littlewood, Tim J., Malcovati, Luca, Della Porta, Matteo G., Jädersten, Martin, Killick, Sally, Giagounidis, Aristoteles, Bowen, David, Hellström-Lindberg, Eva, Cazzola, Mario, Wainscoat, James S.
Publicado em 2008

Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations

Por Scharenberg, Christian, Giai, Valentina, Pellagatti, Andrea, Saft, Leonie, Dimitriou, Marios, Jansson, Monika, Jädersten, Martin, Grandien, Alf, Douagi, Iyadh, Neuberg, Donna S., LeBlanc, Katarina, Boultwood, Jacqueline, Karimi, Mohsen, Jacobsen, Sten Eirik W., Woll, Petter S., Hellström-Lindberg, Eva
Publicado no Haematologica (2017)

Mutation Patterns of 16 Genes in Primary and Secondary Acute Myeloid Leukemia (AML) with Normal Cytogenetics

Por Fernandez-Mercado, Marta, Yip, Bon Ham, Pellagatti, Andrea, Davies, Carwyn, Larrayoz, María José, Kondo, Toshinori, Pérez, Cristina, Killick, Sally, McDonald, Emma-Jane, Odero, María Dolores, Agirre, Xabier, Prósper, Felipe, Calasanz, María José, Wainscoat, James S., Boultwood, Jacqueline
Publicado em 2012

Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes

Por Gerstung, Moritz, Pellagatti, Andrea, Malcovati, Luca, Giagounidis, Aristoteles, Porta, Matteo G Della, Jädersten, Martin, Dolatshad, Hamid, Verma, Amit, Cross, Nicholas C. P., Vyas, Paresh, Killick, Sally, Hellström-Lindberg, Eva, Cazzola, Mario, Papaemmanuil, Elli, Campbell, Peter J., Boultwood, Jacqueline
Publicado no Nat Commun (2015)

Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS

Por Keerthivasan, Ganesan, Mei, Yang, Zhao, Baobing, Zhang, Ling, Harris, Chad E., Gao, Juehua, Basiorka, Ashley A., Schipma, Matthew J., McElherne, James, Yang, Jing, Verma, Amit K., Pellagatti, Andrea, Boultwood, Jacqueline, List, Alan F., Williams, David A., Ji, Peng
Publicado em 2014