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Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression

Clonal heterogeneity has not been described in patients with myelodysplastic syndrome with isolated del(5q), for which lenalidomide has emerged as a highly potent treatment. However, transformation to acute myeloid leukemia is occasionally observed, particularly in patients without a cytogenetic res...

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Détails bibliographiques
Auteurs principaux: Jädersten, Martin, Saft, Leonie, Pellagatti, Andrea, Göhring, Gudrun, Wainscoat, James S., Boultwood, Jacqueline, Porwit, Anna, Schlegelberger, Brigitte, Hellström-Lindberg, Eva
Format: Artigo
Langue:Inglês
Publié: Ferrata Storti Foundation 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791931/
https://ncbi.nlm.nih.gov/pubmed/19797731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.011528
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