Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS

The myelodysplastic syndromes (MDSs) include a spectrum of stem cell malignancies characterized by an increased risk of developing acute myeloid leukemia. Heterozygous loss of chromosome 5q (del[5q]) is the most common cytogenetic abnormality in MDS. DIAPH1 is localized to 5q31 and encodes one of th...

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Hlavní autoři: Keerthivasan, Ganesan, Mei, Yang, Zhao, Baobing, Zhang, Ling, Harris, Chad E., Gao, Juehua, Basiorka, Ashley A., Schipma, Matthew J., McElherne, James, Yang, Jing, Verma, Amit K., Pellagatti, Andrea, Boultwood, Jacqueline, List, Alan F., Williams, David A., Ji, Peng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118486/
https://ncbi.nlm.nih.gov/pubmed/24891322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-552463
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