Loss of mDia1 causes neutropenia via attenuated CD11b endocytosis and increased neutrophil adhesion to the endothelium

Formin protein mDia1 is involved in actin polymerization and plays important roles in the migration and adhesion of hematopoietic cells. The mDia1 encoding gene is located on chromosome 5q, which is commonly deleted in patients with del(5q) myelodysplastic syndromes (MDSs). We previously reported th...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Mei, Yang, Feng, Gong, Rahimi, Nina, Zhao, Baobing, Zhang, Jingxin, Cao, Lan, Yang, Jing, Gao, Juehua, Chen, Yihua, Sumagin, Ronen, Muller, William A., Zhang, Ling, Ji, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728338/
https://ncbi.nlm.nih.gov/pubmed/29296812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007906
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