IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells

Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with disease-initiating stem cells that are not eliminated by conventional therapies. Novel therapeutic targets against preleukemic stem cells need to be identified for potentially curative strategies. We conducted paral...

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Bibliographic Details
Published in:Blood
Main Authors: Schinke, Carolina, Giricz, Orsolya, Li, Weijuan, Shastri, Aditi, Gordon, Shanisha, Barreyro, Laura, Bhagat, Tushar, Bhattacharyya, Sanchari, Ramachandra, Nandini, Bartenstein, Matthias, Pellagatti, Andrea, Boultwood, Jacqueline, Wickrema, Amittha, Yu, Yiting, Will, Britta, Wei, Sheng, Steidl, Ulrich, Verma, Amit
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2015
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432009/
https://ncbi.nlm.nih.gov/pubmed/25810490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-621631
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