Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells

Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with disease-initiating stem cells that are not eliminated by conventional therapies. Transcriptomic analysis of stem and progenitor populations in MDS and AML demonstrated overexpression of STAT3 that was validated in a...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Shastri, Aditi, Choudhary, Gaurav, Teixeira, Margarida, Gordon-Mitchell, Shanisha, Ramachandra, Nandini, Bernard, Lumie, Bhattacharyya, Sanchari, Lopez, Robert, Pradhan, Kith, Giricz, Orsolya, Ravipati, Goutham, Wong, Li-Fan, Cole, Sally, Bhagat, Tushar D., Feld, Jonathan, Dhar, Yosman, Bartenstein, Matthias, Thiruthuvanathan, Victor J., Wickrema, Amittha, Ye, B. Hilda, Frank, David A., Pellagatti, Andrea, Boultwood, Jacqueline, Zhou, Tianyuan, Kim, Youngsoo, MacLeod, A. Robert, Epling-Burnette, P.K., Ye, Minwei, McCoon, Patricia, Woessner, Richard, Steidl, Ulrich, Will, Britta, Verma, Amit
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2018
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264739/
https://ncbi.nlm.nih.gov/pubmed/30252677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120156
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