Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells

Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with disease-initiating stem cells that are not eliminated by conventional therapies. Transcriptomic analysis of stem and progenitor populations in MDS and AML demonstrated overexpression of STAT3 that was validated in a...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Shastri, Aditi, Choudhary, Gaurav, Teixeira, Margarida, Gordon-Mitchell, Shanisha, Ramachandra, Nandini, Bernard, Lumie, Bhattacharyya, Sanchari, Lopez, Robert, Pradhan, Kith, Giricz, Orsolya, Ravipati, Goutham, Wong, Li-Fan, Cole, Sally, Bhagat, Tushar D., Feld, Jonathan, Dhar, Yosman, Bartenstein, Matthias, Thiruthuvanathan, Victor J., Wickrema, Amittha, Ye, B. Hilda, Frank, David A., Pellagatti, Andrea, Boultwood, Jacqueline, Zhou, Tianyuan, Kim, Youngsoo, MacLeod, A. Robert, Epling-Burnette, P.K., Ye, Minwei, McCoon, Patricia, Woessner, Richard, Steidl, Ulrich, Will, Britta, Verma, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264739/
https://ncbi.nlm.nih.gov/pubmed/30252677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120156
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