PRPF8 Defects Cause Missplicing in Myeloid Malignancies

Mutations of spliceosome components are common in myeloid neoplasms. One of the affected genes, PRPF8, encodes the most evolutionarily conserved spliceosomal protein. We identified either recurrent somatic PRPF8 mutations or hemizygous deletions in 15/447 and 24/450 cases, respectively. 50% of PRPF8...

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Detalhes bibliográficos
Main Authors: Kurtovic-Kozaric, Amina, Przychodzen, Bartlomiej, Singh, Jarnail, Konarska, Maria M., Clemente, Michael J., Otrock, Zaher K., Nakashima, Meghan, Hsi, Eric D., Yoshida, Kenichi, Ogawa, Seishi, Boultwood, Jacqueline, Maciejewski, Jaroslaw P., Padgett, Richard A., Makishima, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214909/
https://ncbi.nlm.nih.gov/pubmed/24781015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.144
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