PRPF8 Defects Cause Missplicing in Myeloid Malignancies

Mutations of spliceosome components are common in myeloid neoplasms. One of the affected genes, PRPF8, encodes the most evolutionarily conserved spliceosomal protein. We identified either recurrent somatic PRPF8 mutations or hemizygous deletions in 15/447 and 24/450 cases, respectively. 50% of PRPF8...

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Bibliografiset tiedot
Päätekijät: Kurtovic-Kozaric, Amina, Przychodzen, Bartlomiej, Singh, Jarnail, Konarska, Maria M., Clemente, Michael J., Otrock, Zaher K., Nakashima, Meghan, Hsi, Eric D., Yoshida, Kenichi, Ogawa, Seishi, Boultwood, Jacqueline, Maciejewski, Jaroslaw P., Padgett, Richard A., Makishima, Hideki
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214909/
https://ncbi.nlm.nih.gov/pubmed/24781015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.144
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