Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal disease of hematopoietic stem cells that is associated with hemolysis, marrow failure, and thrombophilia. PNH has been considered a monogenic disease that results from somatic mutations in the gene encoding PIGA, which is required fo...

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Bibliografski detalji
Glavni autori: Shen, Wenyi, Clemente, Michael J., Hosono, Naoko, Yoshida, Kenichi, Przychodzen, Bartlomiej, Yoshizato, Tetsuichi, Shiraishi, Yuichi, Miyano, Satoru, Ogawa, Seishi, Maciejewski, Jaroslaw P., Makishima, Hideki
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2014
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191017/
https://ncbi.nlm.nih.gov/pubmed/25244093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74747
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