Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis

Members of the tristetraprolin family of tandem CCCH finger proteins can bind to AU-rich elements in the 3′-untranslated region of mRNAs, leading to their deadenylation and subsequent degradation. Partial deficiency of 1 of the 4 mouse tristetraprolin family members, Zfp36l2, resulted in complete fe...

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Detalhes bibliográficos
Main Authors: Stumpo, Deborah J., Broxmeyer, Hal E., Ward, Toni, Cooper, Scott, Hangoc, Giao, Chung, Yang Jo, Shelley, William C., Richfield, Eric K., Ray, Manas K., Yoder, Mervin C., Aplan, Peter D., Blackshear, Perry J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746470/
https://ncbi.nlm.nih.gov/pubmed/19633199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-04-214619
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