SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse

SIRT1 is a founding member of a sirtuin family of 7 proteins and histone deacetylases. It is involved in cellular resistance to stress, metabolism, differentiation, aging, and tumor suppression. SIRT1(−/−) mice demonstrate embryonic and postnatal development defects. We examined hematopoietic and en...

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Bibliographic Details
Main Authors: Ou, Xuan, Chae, Hee-Don, Wang, Rui-Hong, Shelley, William C., Cooper, Scott, Taylor, Tammi, Kim, Young-June, Deng, Chu-Xia, Yoder, Mervin C., Broxmeyer, Hal E.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031475/
https://ncbi.nlm.nih.gov/pubmed/20966168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-273011
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