SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization

Nuclear tumor suppressor p53 transactivates proapoptotic genes or antioxidant genes depending on stress severity, while cytoplasmic p53 induces mitochondrial-dependent apoptosis without gene transactivation. Although SIRT1, a p53 deacetylase, inhibits p53-mediated transactivation, how SIRT1 regulate...

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Main Authors: Han, Myung-Kwan, Song, Eun-Kyung, Guo, Ying, Ou, Xuan, Mantel, Charlie, Broxmeyer, Hal E.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819008/
https://ncbi.nlm.nih.gov/pubmed/18371449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.01.002
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