Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability

Karyotypic abnormalities in cultured embryonic stem cells (ESCs), especially near-diploid aneuploidy, are potential obstacles to ESC use in regenerative medicine. Events causing chromosomal abnormalities in ESCs may be related to events in tumor cells causing chromosomal instability (CIN) in human d...

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Detalhes bibliográficos
Main Authors: Mantel, Charlie, Guo, Ying, Lee, Man Ryul, Kim, Min-Kyoung, Han, Myung-Kwan, Shibayama, Hirohiko, Fukuda, Seiji, Yoder, Mervin C., Pelus, Louis M., Kim, Kye-Seong, Broxmeyer, Hal E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Stem Cells in Hematology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885509/
https://ncbi.nlm.nih.gov/pubmed/17289813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-10-054247
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