Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability

Karyotypic abnormalities in cultured embryonic stem cells (ESCs), especially near-diploid aneuploidy, are potential obstacles to ESC use in regenerative medicine. Events causing chromosomal abnormalities in ESCs may be related to events in tumor cells causing chromosomal instability (CIN) in human d...

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Bibliografiske detaljer
Main Authors: Mantel, Charlie, Guo, Ying, Lee, Man Ryul, Kim, Min-Kyoung, Han, Myung-Kwan, Shibayama, Hirohiko, Fukuda, Seiji, Yoder, Mervin C., Pelus, Louis M., Kim, Kye-Seong, Broxmeyer, Hal E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2007
Fag:
Stem Cells in Hematology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885509/
https://ncbi.nlm.nih.gov/pubmed/17289813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-10-054247
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