Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma

LIN28A and LIN28B, the mammalian homologs of lin-28, are implicated in malignant transformation in part because of their ability to promote degradation of the let-7 family of miRs. In the present study, we show that overexpression of Lin28b in vivo leads to an aggressive peripheral T-cell lymphoma (...

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Detalhes bibliográficos
Main Authors: Beachy, Sarah H., Onozawa, Masahiro, Chung, Yang Jo, Slape, Chris, Bilke, Sven, Francis, Princy, Pineda, Marbin, Walker, Robert L., Meltzer, Paul, Aplan, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412328/
https://ncbi.nlm.nih.gov/pubmed/22723554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-401760
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