NUP98-PHF23 is a chromatin modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD domain histone reader function

In this report, we show that expression of a NUP98-PHF23 (NP23) fusion, associated with acute myeloid leukemia (AML) in humans, leads to myeloid, erythroid, T-cell, and B-cell leukemia in mice. The leukemic and pre-leukemic tissues display a stem cell-like expression signature including Hoxa, Hoxb,...

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Hlavní autoři: Gough, Sheryl M, Lee, Fan, Yang, Fan, Walker, Robert L, Zhu, Yeulin J, Pineda, Marbin, Onozawa, Masahiro, Chung, Yang Jo, Bilke, Sven, Wagner, Elise K, Denu, John M, Ning, Yi, Xu, Bowen, Wang, Gang Greg, Meltzer, Paul S, Aplan, Peter D
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018760/
https://ncbi.nlm.nih.gov/pubmed/24535671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0419
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