NUP98-PHF23 is a chromatin modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD domain histone reader function

In this report, we show that expression of a NUP98-PHF23 (NP23) fusion, associated with acute myeloid leukemia (AML) in humans, leads to myeloid, erythroid, T-cell, and B-cell leukemia in mice. The leukemic and pre-leukemic tissues display a stem cell-like expression signature including Hoxa, Hoxb,...

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Detalhes bibliográficos
Main Authors: Gough, Sheryl M, Lee, Fan, Yang, Fan, Walker, Robert L, Zhu, Yeulin J, Pineda, Marbin, Onozawa, Masahiro, Chung, Yang Jo, Bilke, Sven, Wagner, Elise K, Denu, John M, Ning, Yi, Xu, Bowen, Wang, Gang Greg, Meltzer, Paul S, Aplan, Peter D
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018760/
https://ncbi.nlm.nih.gov/pubmed/24535671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0419
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