NUP98-PHF23 is a chromatin modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD domain histone reader function

In this report, we show that expression of a NUP98-PHF23 (NP23) fusion, associated with acute myeloid leukemia (AML) in humans, leads to myeloid, erythroid, T-cell, and B-cell leukemia in mice. The leukemic and pre-leukemic tissues display a stem cell-like expression signature including Hoxa, Hoxb,...

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Huvudupphovsmän: Gough, Sheryl M, Lee, Fan, Yang, Fan, Walker, Robert L, Zhu, Yeulin J, Pineda, Marbin, Onozawa, Masahiro, Chung, Yang Jo, Bilke, Sven, Wagner, Elise K, Denu, John M, Ning, Yi, Xu, Bowen, Wang, Gang Greg, Meltzer, Paul S, Aplan, Peter D
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018760/
https://ncbi.nlm.nih.gov/pubmed/24535671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0419
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