Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background

Approximately 10% of NUP98-PHF23 (NP23) mice develop an aggressive acute lymphoblastic leukemia of B-1 lymphocyte progenitor origin (pro-B1 ALL), accompanied by somatic frameshift mutations of the BCL6 interacting corepressor (Bcor) gene, most commonly within a 9-bp “hotspot” in Bcor exon 8. To dete...

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Publicado en:Blood
Autores principales: Yin, Mianmian, Chung, Yang Jo, Lindsley, R. Coleman, Walker, Robert L., Zhu, Yuelin J., Ebert, Benjamin L., Meltzer, Paul S., Aplan, Peter D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2019
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566592/
https://ncbi.nlm.nih.gov/pubmed/30992267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018864173
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