EBI2 overexpression in mice leads to B1 B-cell expansion and chronic lymphocytic leukemia–like B-cell malignancies

Human and mouse chronic lymphocytic leukemia (CLL) develops from CD5(+) B cells that in mice and macaques are known to define the distinct B1a B-cell lineage. B1a cells are characterized by lack of germinal center (GC) development, and the B1a cell population is increased in mice with reduced GC for...

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Publicado en:Blood
Autores principales: Niss Arfelt, Kristine, Barington, Line, Benned-Jensen, Tau, Kubale, Valentina, Kovalchuk, Alexander L., Daugvilaite, Viktorija, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Egerod, Kristoffer L., Bassi, Maria R., Spiess, Katja, Schwartz, Thue W., Wang, Hongsheng, Morse, Herbert C., Holst, Peter J., Rosenkilde, Mette M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2017
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314812/
https://ncbi.nlm.nih.gov/pubmed/28003273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-02-697185
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