Ligand Modulation of the Epstein-Barr Virus-induced Seven-transmembrane Receptor EBI2: IDENTIFICATION OF A POTENT AND EFFICACIOUS INVERSE AGONIST

The Epstein-Barr virus-induced receptor 2 (EBI2) is a constitutively active seven-transmembrane receptor, which was recently shown to orchestrate the positioning of B cells in the follicle. To date, no ligands, endogenously or synthetic, have been identified that modulate EBI2 activity. Here we desc...

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Detalhes bibliográficos
Main Authors: Benned-Jensen, Tau, Smethurst, Christopher, Holst, Peter J., Page, Kevin R., Sauls, Howard, Sivertsen, Bjørn, Schwartz, Thue W., Blanchard, Andy, Jepras, Robert, Rosenkilde, Mette M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190735/
https://ncbi.nlm.nih.gov/pubmed/21673108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.196345
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