A Conserved Aromatic Lock for the Tryptophan Rotameric Switch in TM-VI of Seven-transmembrane Receptors

The conserved tryptophan in position 13 of TM-VI (Trp-VI:13 or Trp-6.48) of the CWXP motif located at the bottom of the main ligand-binding pocket in TM-VI is believed to function as a rotameric microswitch in the activation process of seven-transmembrane (7TM) receptors. Molecular dynamics simulati...

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Main Authors: Holst, Birgitte, Nygaard, Rie, Valentin-Hansen, Louise, Bach, Anders, Engelstoft, Maja S., Petersen, Pia S., Frimurer, Thomas M., Schwartz, Thue W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823539/
https://ncbi.nlm.nih.gov/pubmed/19920139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064725
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