Unique Interaction Pattern for a Functionally Biased Ghrelin Receptor Agonist

Based on the conformationally constrained d-Trp-Phe-d-Trp (wFw) core of the prototype inverse agonist [d-Arg(1),d-Phe(5),d-Trp(7,9),Leu(11)]substance P, a series of novel, small, peptide-mimetic agonists for the ghrelin receptor were generated. By using various simple, ring-constrained spacers conne...

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Detalhes bibliográficos
Main Authors: Sivertsen, Bjørn, Lang, Manja, Frimurer, Thomas M., Holliday, Nicholas D., Bach, Anders, Els, Sylvia, Engelstoft, Maja S., Petersen, Pia S., Madsen, Andreas N., Schwartz, Thue W., Beck-Sickinger, Annette G., Holst, Birgitte
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121491/
https://ncbi.nlm.nih.gov/pubmed/21402696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.173237
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