Translating biased signaling in the ghrelin receptor system into differential in vivo functions

Biased signaling has been suggested as a means of selectively modulating a limited fraction of the signaling pathways for G-protein–coupled receptor family members. Hence, biased ligands may allow modulation of only the desired physiological functions and not elicit undesired effects associated with...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Mende, Franziska, Hundahl, Cecilie, Plouffe, Bianca, Skov, Louise Julie, Sivertsen, Bjørn, Madsen, Andreas Nygaard, Lückmann, Michael, Diep, Thi Ai, Offermanns, Stefan, Frimurer, Thomas Michael, Bouvier, Michel, Holst, Birgitte
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205473/
https://ncbi.nlm.nih.gov/pubmed/30301804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804003115
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