Modulation of Constitutive Activity and Signaling Bias of the Ghrelin Receptor by Conformational Constraint in the Second Extracellular Loop

Based on a rare, natural Glu for Ala-204(C+6) variant located six residues after the conserved Cys residue in extracellular loop 2b (ECL2b) associated with selective elimination of the high constitutive signaling of the ghrelin receptor, this loop was subjected to a detailed structure functional ana...

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Bibliografiska uppgifter
Huvudupphovsmän: Mokrosiński, Jacek, Frimurer, Thomas M., Sivertsen, Bjørn, Schwartz, Thue W., Holst, Birgitte
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460450/
https://ncbi.nlm.nih.gov/pubmed/22846991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.383240
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