Assessment and Challenges of Ligand Docking into Comparative Models of G-Protein Coupled Receptors

Por Nguyen, Elizabeth Dong, Norn, Christoffer, Frimurer, Thomas M., Meiler, Jens
Publicado em 2013

PheVI:09 (Phe6.44) as a Sliding Microswitch in Seven-transmembrane (7TM) G Protein-coupled Receptor Activation

Por Valentin-Hansen, Louise, Holst, Birgitte, Frimurer, Thomas M., Schwartz, Thue W.
Publicado em 2012

Modulation of Constitutive Activity and Signaling Bias of the Ghrelin Receptor by Conformational Constraint in the Second Extracellular Loop

Por Mokrosiński, Jacek, Frimurer, Thomas M., Sivertsen, Bjørn, Schwartz, Thue W., Holst, Birgitte
Publicado em 2012

Conserved Water-mediated Hydrogen Bond Network between TM-I, -II, -VI, and -VII in 7TM Receptor Activation

Por Nygaard, Rie, Valentin-Hansen, Louise, Mokrosinski, Jacek, Frimurer, Thomas M., Schwartz, Thue W.
Publicado em 2010

Biased and Constitutive Signaling in the CC-chemokine Receptor CCR5 by Manipulating the Interface between Transmembrane Helices 6 and 7

Por Steen, Anne, Thiele, Stefanie, Guo, Dong, Hansen, Lærke S., Frimurer, Thomas M., Rosenkilde, Mette M.
Publicado em 2013

Biased G(s) Versus G(q) Proteins and β-Arrestin Signaling in the NK1 Receptor Determined by Interactions in the Water Hydrogen Bond Network

Por Valentin-Hansen, Louise, Frimurer, Thomas M., Mokrosinski, Jacek, Holliday, Nicholas D., Schwartz, Thue W.
Publicado no J Biol Chem (2015)

Allosteric and Orthosteric Sites in CC Chemokine Receptor (CCR5), a Chimeric Receptor Approach

Por Thiele, Stefanie, Steen, Anne, Jensen, Pia C., Mokrosinski, Jacek, Frimurer, Thomas M., Rosenkilde, Mette M.
Publicado em 2011

The Arginine of the DRY Motif in Transmembrane Segment III Functions as a Balancing Micro-switch in the Activation of the β2-Adrenergic Receptor

Por Valentin-Hansen, Louise, Groenen, Marleen, Nygaard, Rie, Frimurer, Thomas M., Holliday, Nicholas D., Schwartz, Thue W.
Publicado em 2012

Ligand-Induced Conformational Changes: Improved Predictions of Ligand Binding Conformations and Affinities

Por Frimurer, Thomas M., Peters, Günther H., Iversen, Lars F., Andersen, Henrik S., Møller, Niels Peter H., Olsen, Ole H.
Publicado em 2003

A Conserved Aromatic Lock for the Tryptophan Rotameric Switch in TM-VI of Seven-transmembrane Receptors

Por Holst, Birgitte, Nygaard, Rie, Valentin-Hansen, Louise, Bach, Anders, Engelstoft, Maja S., Petersen, Pia S., Frimurer, Thomas M., Schwartz, Thue W.
Publicado em 2010

Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding

Por Barington, Line, Rummel, Pia C., Lückmann, Michael, Pihl, Heidi, Larsen, Olav, Daugvilaite, Viktorija, Johnsen, Anders H., Frimurer, Thomas M., Karlshøj, Stefanie, Rosenkilde, Mette M.
Publicado no J Biol Chem (2016)

Unique Interaction Pattern for a Functionally Biased Ghrelin Receptor Agonist

Por Sivertsen, Bjørn, Lang, Manja, Frimurer, Thomas M., Holliday, Nicholas D., Bach, Anders, Els, Sylvia, Engelstoft, Maja S., Petersen, Pia S., Madsen, Andreas N., Schwartz, Thue W., Beck-Sickinger, Annette G., Holst, Birgitte
Publicado em 2011

GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

Por Hauge, Maria, Vestmar, Marie A., Husted, Anna S., Ekberg, Jeppe P., Wright, Michael J., Di Salvo, Jerry, Weinglass, Adam B., Engelstoft, Maja S., Madsen, Andreas N., Lückmann, Michael, Miller, Michael W., Trujillo, Maria E., Frimurer, Thomas M., Holst, Birgitte, Howard, Andrew D., Schwartz, Thue W.
Publicado no Mol Metab (2014)