The Arginine of the DRY Motif in Transmembrane Segment III Functions as a Balancing Micro-switch in the Activation of the β2-Adrenergic Receptor

Recent high resolution x-ray structures of the β2-adrenergic receptor confirmed a close salt-bridge interaction between the suspected micro-switch residue ArgIII:26 (Arg3.50) and the neighboring AspIII:25 (Asp3.49). However, neither the expected “ionic lock” interactions between ArgIII:26 and GluVI:...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Valentin-Hansen, Louise, Groenen, Marleen, Nygaard, Rie, Frimurer, Thomas M., Holliday, Nicholas D., Schwartz, Thue W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442529/
https://ncbi.nlm.nih.gov/pubmed/22843684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.348565
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados