The Arginine of the DRY Motif in Transmembrane Segment III Functions as a Balancing Micro-switch in the Activation of the β2-Adrenergic Receptor

Recent high resolution x-ray structures of the β2-adrenergic receptor confirmed a close salt-bridge interaction between the suspected micro-switch residue ArgIII:26 (Arg3.50) and the neighboring AspIII:25 (Asp3.49). However, neither the expected “ionic lock” interactions between ArgIII:26 and GluVI:...

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Détails bibliographiques
Auteurs principaux: Valentin-Hansen, Louise, Groenen, Marleen, Nygaard, Rie, Frimurer, Thomas M., Holliday, Nicholas D., Schwartz, Thue W.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442529/
https://ncbi.nlm.nih.gov/pubmed/22843684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.348565
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