Biased G(s) Versus G(q) Proteins and β-Arrestin Signaling in the NK1 Receptor Determined by Interactions in the Water Hydrogen Bond Network

X-ray structures, molecular dynamics simulations, and mutational analysis have previously indicated that an extended water hydrogen bond network between trans-membranes I–III, VI, and VII constitutes an allosteric interface essential for stabilizing different active and inactive helical constellatio...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Valentin-Hansen, Louise, Frimurer, Thomas M., Mokrosinski, Jacek, Holliday, Nicholas D., Schwartz, Thue W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591830/
https://ncbi.nlm.nih.gov/pubmed/26269596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.641944
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