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Biased G(s) Versus G(q) Proteins and β-Arrestin Signaling in the NK1 Receptor Determined by Interactions in the Water Hydrogen Bond Network
X-ray structures, molecular dynamics simulations, and mutational analysis have previously indicated that an extended water hydrogen bond network between trans-membranes I–III, VI, and VII constitutes an allosteric interface essential for stabilizing different active and inactive helical constellatio...
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| Pubblicato in: | J Biol Chem |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4591830/ https://ncbi.nlm.nih.gov/pubmed/26269596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.641944 |
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