Biased and Constitutive Signaling in the CC-chemokine Receptor CCR5 by Manipulating the Interface between Transmembrane Helices 6 and 7

The equilibrium state of CCR5 is manipulated here toward either activation or inactivation by introduction of single amino acid substitutions in the transmembrane domains (TMs) 6 and 7. Insertion of a steric hindrance mutation in the center of TM7 (G286F in position VII:09/7.42) resulted in biased s...

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Bibliographic Details
Main Authors: Steen, Anne, Thiele, Stefanie, Guo, Dong, Hansen, Lærke S., Frimurer, Thomas M., Rosenkilde, Mette M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642299/
https://ncbi.nlm.nih.gov/pubmed/23493400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.449587
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