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Allosteric and Orthosteric Sites in CC Chemokine Receptor (CCR5), a Chimeric Receptor Approach

Chemokine receptors play a major role in immune system regulation and have consequently been targets for drug development leading to the discovery of several small molecule antagonists. Given the large size and predominantly extracellular receptor interaction of endogenous chemokines, small molecule...

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Hlavní autoři: Thiele, Stefanie, Steen, Anne, Jensen, Pia C., Mokrosinski, Jacek, Frimurer, Thomas M., Rosenkilde, Mette M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199500/
https://ncbi.nlm.nih.gov/pubmed/21878623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.243808
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