Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

CC chemokine receptor 2 (CCR2) is one of 19 members of the chemokine receptor subfamily of human Class A G protein-coupled receptors (GPCRs). CCR2 is expressed on monocytes, immature dendritic cells and T cell subpopulations, and mediates their migration towards endogenous CC chemokine ligands such...

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Publicado no:Nature
Main Authors: Zheng, Yi, Qin, Ling, Ortiz Zacarías, Natalia V., de Vries, Henk, Han, Gye Won, Gustavsson, Martin, Dabros, Marta, Zhao, Chunxia, Cherney, Robert J., Carter, Percy, Stamos, Dean, Abagyan, Ruben, Cherezov, Vadim, Stevens, Raymond C., IJzerman, Adriaan P., Heitman, Laura H., Tebben, Andrew, Kufareva, Irina, Handel, Tracy M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159191/
https://ncbi.nlm.nih.gov/pubmed/27926736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20605
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