Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV

CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes, whereas CCR5 ligands inhibit infection by blocking CCR5 engagement with HIV gp120. To guide the design of improved therapeutics, we solved the structure of CCR5 in complex with chemokine antagonist [5P7]CCL5. Several struct...

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Bibliografiska uppgifter
I publikationen:Immunity
Huvudupphovsmän: Zheng, Yi, Han, Gye Won, Abagyan, Ruben, Wu, Beili, Stevens, Raymond C., Cherezov, Vadim, Kufareva, Irina, Handel, Tracy M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572563/
https://ncbi.nlm.nih.gov/pubmed/28636951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.05.002
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