Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV

CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes, whereas CCR5 ligands inhibit infection by blocking CCR5 engagement with HIV gp120. To guide the design of improved therapeutics, we solved the structure of CCR5 in complex with chemokine antagonist [5P7]CCL5. Several struct...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Zheng, Yi, Han, Gye Won, Abagyan, Ruben, Wu, Beili, Stevens, Raymond C., Cherezov, Vadim, Kufareva, Irina, Handel, Tracy M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572563/
https://ncbi.nlm.nih.gov/pubmed/28636951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.05.002
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