Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV

CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes, whereas CCR5 ligands inhibit infection by blocking CCR5 engagement with HIV gp120. To guide the design of improved therapeutics, we solved the structure of CCR5 in complex with chemokine antagonist [5P7]CCL5. Several struct...

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Enregistré dans:
Détails bibliographiques
Publié dans:Immunity
Auteurs principaux: Zheng, Yi, Han, Gye Won, Abagyan, Ruben, Wu, Beili, Stevens, Raymond C., Cherezov, Vadim, Kufareva, Irina, Handel, Tracy M.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572563/
https://ncbi.nlm.nih.gov/pubmed/28636951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.05.002
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