Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2

[Image: see text] The recent crystal structures of CC chemokine receptors 2 and 9 (CCR2 and CCR9) have provided structural evidence for an allosteric, intracellular binding site. The high conservation of residues involved in this site suggests its presence in most chemokine receptors, including the...

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Gepubliceerd in:J Med Chem
Hoofdauteurs: Ortiz Zacarías, Natalia V., van Veldhoven, Jacobus P. D., Portner, Laura, van Spronsen, Eric, Ullo, Salviana, Veenhuizen, Margo, van der Velden, Wijnand J. C., Zweemer, Annelien J. M., Kreekel, Roy M., Oenema, Kenny, Lenselink, Eelke B., Heitman, Laura H., IJzerman, Adriaan P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2018
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328288/
https://ncbi.nlm.nih.gov/pubmed/30256641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00605
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