Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2

[Image: see text] The recent crystal structures of CC chemokine receptors 2 and 9 (CCR2 and CCR9) have provided structural evidence for an allosteric, intracellular binding site. The high conservation of residues involved in this site suggests its presence in most chemokine receptors, including the...

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Bibliographic Details
Published in:J Med Chem
Main Authors: Ortiz Zacarías, Natalia V., van Veldhoven, Jacobus P. D., Portner, Laura, van Spronsen, Eric, Ullo, Salviana, Veenhuizen, Margo, van der Velden, Wijnand J. C., Zweemer, Annelien J. M., Kreekel, Roy M., Oenema, Kenny, Lenselink, Eelke B., Heitman, Laura H., IJzerman, Adriaan P.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2018
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328288/
https://ncbi.nlm.nih.gov/pubmed/30256641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00605
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