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A covalent antagonist for the human adenosine A(2A) receptor

The structure of the human A(2A) adenosine receptor has been elucidated by X-ray crystallography with a high affinity non-xanthine antagonist, ZM241385, bound to it. This template molecule served as a starting point for the incorporation of reactive moieties that cause the ligand to covalently bind...

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Detalhes bibliográficos
Publicado no:Purinergic Signal
Main Authors: Yang, Xue, Dong, Guo, Michiels, Thomas J.M., Lenselink, Eelke B., Heitman, Laura, Louvel, Julien, IJzerman, Ad P.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432479/
https://ncbi.nlm.nih.gov/pubmed/27915383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-016-9549-9
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