Structure–Affinity Relationships and Structure–Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A(3) Receptor Antagonists

[Image: see text] We expanded on a series of pyrido[2,1-f]purine-2,4-dione derivatives as human adenosine A(3) receptor (hA(3)R) antagonists to determine their kinetic profiles and affinities. Many compounds showed high affinities and a diverse range of kinetic profiles. We found hA(3)R antagonists...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Xia, Lizi, Burger, Wessel A. C., van Veldhoven, Jacobus P. D., Kuiper, Boaz J., van Duijl, Tirsa T., Lenselink, Eelke B., Paasman, Ellen, Heitman, Laura H., IJzerman, Adriaan P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601358/
https://ncbi.nlm.nih.gov/pubmed/28806076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00950
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