Gating function of isoleucine-116 in TM-3 (position III:16/3.40) for the activity state of the CC-chemokine receptor 5 (CCR5)

BACKGROUND AND PURPOSE: A conserved amino acid within a protein family indicates a significance of the residue. In the centre of transmembrane helix (TM)-5, position V:13/5.47, an aromatic amino acid is conserved among class A 7TM receptors. However, in 37% of chemokine receptors – a subgroup of 7TM...

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Bibliografske podrobnosti
Main Authors: Steen, A, Sparre-Ulrich, A H, Thiele, S, Guo, D, Frimurer, T M, Rosenkilde, M M
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2014
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954493/
https://ncbi.nlm.nih.gov/pubmed/24328926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12553
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