Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

The CCR7 ligands CCL19 and CCL21 are increasingly recognized as functionally different (biased). Using mature human dendritic cells (DCs), we show that CCL19 is more potent than CCL21 in inducing 3D chemotaxis. Intriguingly, CCL21 induces prolonged and more efficient ERK1/2 activation compared with...

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Udgivet i:Front Immunol
Main Authors: Hjortø, Gertrud M., Larsen, Olav, Steen, Anne, Daugvilaite, Viktorija, Berg, Christian, Fares, Suzan, Hansen, Morten, Ali, Simi, Rosenkilde, Mette M.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145889/
https://ncbi.nlm.nih.gov/pubmed/28018341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00568
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