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Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

The CCR7 ligands CCL19 and CCL21 are increasingly recognized as functionally different (biased). Using mature human dendritic cells (DCs), we show that CCL19 is more potent than CCL21 in inducing 3D chemotaxis. Intriguingly, CCL21 induces prolonged and more efficient ERK1/2 activation compared with...

詳細記述

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書誌詳細
出版年:Front Immunol
主要な著者: Hjortø, Gertrud M., Larsen, Olav, Steen, Anne, Daugvilaite, Viktorija, Berg, Christian, Fares, Suzan, Hansen, Morten, Ali, Simi, Rosenkilde, Mette M.
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145889/
https://ncbi.nlm.nih.gov/pubmed/28018341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00568
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