Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

The CCR7 ligands CCL19 and CCL21 are increasingly recognized as functionally different (biased). Using mature human dendritic cells (DCs), we show that CCL19 is more potent than CCL21 in inducing 3D chemotaxis. Intriguingly, CCL21 induces prolonged and more efficient ERK1/2 activation compared with...

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Bibliografische gegevens
Gepubliceerd in:Front Immunol
Hoofdauteurs: Hjortø, Gertrud M., Larsen, Olav, Steen, Anne, Daugvilaite, Viktorija, Berg, Christian, Fares, Suzan, Hansen, Morten, Ali, Simi, Rosenkilde, Mette M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2016
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145889/
https://ncbi.nlm.nih.gov/pubmed/28018341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00568
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