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Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines
The CCR7 ligands CCL19 and CCL21 are increasingly recognized as functionally different (biased). Using mature human dendritic cells (DCs), we show that CCL19 is more potent than CCL21 in inducing 3D chemotaxis. Intriguingly, CCL21 induces prolonged and more efficient ERK1/2 activation compared with...
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| Publicat a: | Front Immunol |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Frontiers Media S.A.
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5145889/ https://ncbi.nlm.nih.gov/pubmed/28018341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00568 |
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