Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)

The small molecule metal ion chelators bipyridine and terpyridine complexed with Zn(2+) (ZnBip and ZnTerp) act as CCR5 agonists and strong positive allosteric modulators of CCL3 binding to CCR5, weak modulators of CCL4 binding, and competitors for CCL5 binding. Here we describe their binding site us...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Karlshøj, Stefanie, Amarandi, Roxana Maria, Larsen, Olav, Daugvilaite, Viktorija, Steen, Anne, Brvar, Matjaž, Pui, Aurel, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette Marie
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2016
Aiheet:
Computational Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207192/
https://ncbi.nlm.nih.gov/pubmed/27834679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.740183
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia