Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)

The small molecule metal ion chelators bipyridine and terpyridine complexed with Zn(2+) (ZnBip and ZnTerp) act as CCR5 agonists and strong positive allosteric modulators of CCL3 binding to CCR5, weak modulators of CCL4 binding, and competitors for CCL5 binding. Here we describe their binding site us...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Karlshøj, Stefanie, Amarandi, Roxana Maria, Larsen, Olav, Daugvilaite, Viktorija, Steen, Anne, Brvar, Matjaž, Pui, Aurel, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette Marie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Computational Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207192/
https://ncbi.nlm.nih.gov/pubmed/27834679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.740183
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