Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)

The small molecule metal ion chelators bipyridine and terpyridine complexed with Zn(2+) (ZnBip and ZnTerp) act as CCR5 agonists and strong positive allosteric modulators of CCL3 binding to CCR5, weak modulators of CCL4 binding, and competitors for CCL5 binding. Here we describe their binding site us...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Karlshøj, Stefanie, Amarandi, Roxana Maria, Larsen, Olav, Daugvilaite, Viktorija, Steen, Anne, Brvar, Matjaž, Pui, Aurel, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Computational Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207192/
https://ncbi.nlm.nih.gov/pubmed/27834679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.740183
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