Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding

Chemokine receptors play important roles in the immune system and are linked to several human diseases. The initial contact of chemokines with their receptors depends on highly specified extracellular receptor features. Here we investigate the importance of conserved extracellular disulfide bridges...

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Vydáno v:J Biol Chem
Hlavní autoři: Barington, Line, Rummel, Pia C., Lückmann, Michael, Pihl, Heidi, Larsen, Olav, Daugvilaite, Viktorija, Johnsen, Anders H., Frimurer, Thomas M., Karlshøj, Stefanie, Rosenkilde, Mette M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965569/
https://ncbi.nlm.nih.gov/pubmed/27226537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.706747
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