Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding

Chemokine receptors play important roles in the immune system and are linked to several human diseases. The initial contact of chemokines with their receptors depends on highly specified extracellular receptor features. Here we investigate the importance of conserved extracellular disulfide bridges...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Barington, Line, Rummel, Pia C., Lückmann, Michael, Pihl, Heidi, Larsen, Olav, Daugvilaite, Viktorija, Johnsen, Anders H., Frimurer, Thomas M., Karlshøj, Stefanie, Rosenkilde, Mette M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965569/
https://ncbi.nlm.nih.gov/pubmed/27226537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.706747
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