Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

The CCR7 ligands CCL19 and CCL21 are increasingly recognized as functionally different (biased). Using mature human dendritic cells (DCs), we show that CCL19 is more potent than CCL21 in inducing 3D chemotaxis. Intriguingly, CCL21 induces prolonged and more efficient ERK1/2 activation compared with...

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Bibliografski detalji
Izdano u:Front Immunol
Glavni autori: Hjortø, Gertrud M., Larsen, Olav, Steen, Anne, Daugvilaite, Viktorija, Berg, Christian, Fares, Suzan, Hansen, Morten, Ali, Simi, Rosenkilde, Mette M.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2016
Teme:
Immunology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145889/
https://ncbi.nlm.nih.gov/pubmed/28018341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00568
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