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Allosteric and Orthosteric Sites in CC Chemokine Receptor (CCR5), a Chimeric Receptor Approach

Chemokine receptors play a major role in immune system regulation and have consequently been targets for drug development leading to the discovery of several small molecule antagonists. Given the large size and predominantly extracellular receptor interaction of endogenous chemokines, small molecule...

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מידע ביבליוגרפי
Main Authors: Thiele, Stefanie, Steen, Anne, Jensen, Pia C., Mokrosinski, Jacek, Frimurer, Thomas M., Rosenkilde, Mette M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199500/
https://ncbi.nlm.nih.gov/pubmed/21878623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.243808
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